| Regular Season: Week 1 |
 Vikings |
at |
 Saints |
Sunday, September 3, 1978 |
3:00PM |
MIN 24, NO 31 |
| Regular Season: Week 2 |
Saints |
at |
 Packers |
Sunday, September 10, 1978 |
3:00PM |
NO 17, GB 28 |
| Regular Season: Week 3 |
 Eagles |
at |
Saints |
Sunday, September 17, 1978 |
3:00PM |
PHI 24, NO 17 |
| Regular Season: Week 4 |
Saints |
at |
 Bengals |
Sunday, September 24, 1978 |
3:00PM |
NO 20, CIN 18 |
| Regular Season: Week 5 |
 Rams |
at |
Saints |
Sunday, October 1, 1978 |
3:00PM |
LA 26, NO 20 |
| Regular Season: Week 6 |
 Browns |
at |
Saints |
Sunday, October 8, 1978 |
3:00PM |
CLE 24, NO 16 |
| Regular Season: Week 7 |
Saints |
at |
 49ers |
Sunday, October 15, 1978 |
3:00PM |
NO 14, SF 7 |
| Regular Season: Week 8 |
Saints |
at |
Rams |
Sunday, October 22, 1978 |
3:00PM |
NO 10, LA 3 |
| Regular Season: Week 9 |
 Giants |
at |
Saints |
Sunday, October 29, 1978 |
2:00PM |
NYG 17, NO 28 |
| Regular Season: Week 10 |
Saints |
at |
 Steelers |
Sunday, November 5, 1978 |
3:00PM |
NO 14, PIT 20 |
| Regular Season: Week 11 |
 Falcons |
at |
Saints |
Sunday, November 12, 1978 |
3:00PM |
ATL 20, NO 17 |
| Regular Season: Week 12 |
Saints |
at |
 Cowboys |
Sunday, November 19, 1978 |
3:00PM |
NO 7, DAL 27 |
| Regular Season: Week 13 |
Saints |
at |
Falcons |
Sunday, November 26, 1978 |
3:00PM |
NO 17, ATL 20 |
| Regular Season: Week 14 |
49ers |
at |
Saints |
Sunday, December 3, 1978 |
3:00PM |
SF 13, NO 24 |
| Regular Season: Week 15 |
 Oilers |
at |
Saints |
Sunday, December 10, 1978 |
3:00PM |
HOU 17, NO 12 |
| Regular Season: Week 16 |
Saints |
at |
 Buccaneers |
Sunday, December 17, 1978 |
3:00PM |
NO 17, TB 10 |