| Regular Season: Week 1 |
 49ers |
at |
 Saints |
Sunday, September 7, 1980 |
3:00PM |
SF 26, NO 23 |
| Regular Season: Week 2 |
Saints |
at |
 Bears |
Sunday, September 14, 1980 |
3:00PM |
NO 3, CHI 22 |
| Regular Season: Week 3 |
 Bills |
at |
Saints |
Sunday, September 21, 1980 |
3:00PM |
BUF 35, NO 26 |
| Regular Season: Week 4 |
Saints |
at |
 Dolphins |
Sunday, September 28, 1980 |
3:00PM |
NO 16, MIA 21 |
| Regular Season: Week 5 |
 Cardinals |
at |
Saints |
Sunday, October 5, 1980 |
3:00PM |
STL 40, NO 7 |
| Regular Season: Week 6 |
Saints |
at |
 Lions |
Sunday, October 12, 1980 |
3:00PM |
NO 13, DET 24 |
| Regular Season: Week 7 |
 Falcons |
at |
Saints |
Sunday, October 19, 1980 |
3:00PM |
ATL 41, NO 14 |
| Regular Season: Week 8 |
Saints |
at |
 Redskins |
Sunday, October 26, 1980 |
2:00PM |
NO 14, WAS 22 |
| Regular Season: Week 9 |
Saints |
at |
 Rams |
Sunday, November 2, 1980 |
3:00PM |
NO 31, LA 45 |
| Regular Season: Week 10 |
 Eagles |
at |
Saints |
Sunday, November 9, 1980 |
3:00PM |
PHI 34, NO 21 |
| Regular Season: Week 11 |
Saints |
at |
Falcons |
Sunday, November 16, 1980 |
3:00PM |
NO 13, ATL 31 |
| Regular Season: Week 12 |
Rams |
at |
Saints |
Monday, November 24, 1980 |
3:00PM |
LA 27, NO 7 |
| Regular Season: Week 13 |
 Vikings |
at |
Saints |
Sunday, November 30, 1980 |
3:00PM |
MIN 23, NO 20 |
| Regular Season: Week 14 |
Saints |
at |
49ers |
Sunday, December 7, 1980 |
3:00PM |
NO 35, SF 38 |
| Regular Season: Week 15 |
Saints |
at |
 Jets |
Sunday, December 14, 1980 |
3:00PM |
NO 21, NYJ 20 |
| Regular Season: Week 16 |
 Patriots |
at |
Saints |
Sunday, December 21, 1980 |
3:00PM |
NE 38, NO 27 |