| Regular Season: Week 1 |
 Saints |
at |
 Falcons |
Sunday, September 6, 1981 |
3:00PM |
NO 0, ATL 27 |
| Regular Season: Week 2 |
 Rams |
at |
Saints |
Sunday, September 13, 1981 |
3:00PM |
LA 17, NO 23 |
| Regular Season: Week 3 |
Saints |
at |
 Giants |
Sunday, September 20, 1981 |
3:00PM |
NO 7, NYG 20 |
| Regular Season: Week 4 |
Saints |
at |
 49ers |
Sunday, September 27, 1981 |
3:00PM |
NO 14, SF 21 |
| Regular Season: Week 5 |
 Steelers |
at |
Saints |
Sunday, October 4, 1981 |
3:00PM |
PIT 20, NO 6 |
| Regular Season: Week 6 |
 Eagles |
at |
Saints |
Sunday, October 11, 1981 |
3:00PM |
PHI 31, NO 14 |
| Regular Season: Week 7 |
Saints |
at |
 Browns |
Sunday, October 18, 1981 |
3:00PM |
NO 17, CLE 20 |
| Regular Season: Week 8 |
 Bengals |
at |
Saints |
Sunday, October 25, 1981 |
2:00PM |
CIN 7, NO 17 |
| Regular Season: Week 9 |
Falcons |
at |
Saints |
Sunday, November 1, 1981 |
3:00PM |
ATL 41, NO 10 |
| Regular Season: Week 10 |
Saints |
at |
Rams |
Sunday, November 8, 1981 |
3:00PM |
NO 21, LA 13 |
| Regular Season: Week 11 |
Saints |
at |
 Vikings |
Sunday, November 15, 1981 |
3:00PM |
NO 10, MIN 20 |
| Regular Season: Week 12 |
Saints |
at |
 Oilers |
Sunday, November 22, 1981 |
3:00PM |
NO 27, HOU 24 |
| Regular Season: Week 13 |
 Buccaneers |
at |
Saints |
Sunday, November 29, 1981 |
3:00PM |
TB 31, NO 14 |
| Regular Season: Week 14 |
Saints |
at |
 Cardinals |
Sunday, December 6, 1981 |
3:00PM |
NO 3, STL 30 |
| Regular Season: Week 15 |
 Packers |
at |
Saints |
Sunday, December 13, 1981 |
3:00PM |
GB 35, NO 7 |
| Regular Season: Week 16 |
49ers |
at |
Saints |
Sunday, December 20, 1981 |
3:00PM |
SF 21, NO 17 |