| Regular Season: Week 1 |
 49ers |
at |
 Saints |
Sunday, September 4, 1988 |
3:00PM |
SF 34, NO 33 |
| Regular Season: Week 2 |
Saints |
at |
 Falcons |
Sunday, September 11, 1988 |
3:00PM |
NO 29, ATL 21 |
| Regular Season: Week 3 |
Saints |
at |
 Lions |
Sunday, September 18, 1988 |
3:00PM |
NO 22, DET 14 |
| Regular Season: Week 4 |
 Buccaneers |
at |
Saints |
Sunday, September 25, 1988 |
3:00PM |
TB 9, NO 13 |
| Regular Season: Week 5 |
 Cowboys |
at |
Saints |
Monday, October 3, 1988 |
3:00PM |
DAL 17, NO 20 |
| Regular Season: Week 6 |
Saints |
at |
 Chargers |
Sunday, October 9, 1988 |
3:00PM |
NO 23, SD 17 |
| Regular Season: Week 7 |
Saints |
at |
 Seahawks |
Sunday, October 16, 1988 |
3:00PM |
NO 20, SEA 19 |
| Regular Season: Week 8 |
 Raiders |
at |
Saints |
Sunday, October 23, 1988 |
3:00PM |
RAI 6, NO 20 |
| Regular Season: Week 9 |
 Rams |
at |
Saints |
Sunday, October 30, 1988 |
2:00PM |
RAM 12, NO 10 |
| Regular Season: Week 10 |
Saints |
at |
 Redskins |
Sunday, November 6, 1988 |
3:00PM |
NO 24, WAS 27 |
| Regular Season: Week 11 |
Saints |
at |
Rams |
Sunday, November 13, 1988 |
3:00PM |
NO 14, RAM 10 |
| Regular Season: Week 12 |
 Broncos |
at |
Saints |
Sunday, November 20, 1988 |
3:00PM |
DEN 0, NO 42 |
| Regular Season: Week 13 |
 Giants |
at |
Saints |
Sunday, November 27, 1988 |
3:00PM |
NYG 13, NO 12 |
| Regular Season: Week 14 |
Saints |
at |
 Vikings |
Sunday, December 4, 1988 |
3:00PM |
NO 3, MIN 45 |
| Regular Season: Week 15 |
Saints |
at |
49ers |
Sunday, December 11, 1988 |
3:00PM |
NO 17, SF 30 |
| Regular Season: Week 16 |
Falcons |
at |
Saints |
Sunday, December 18, 1988 |
3:00PM |
ATL 9, NO 10 |