| Regular Season: Week 1 |
 Packers |
at |
 Saints |
Sunday, September 12, 2021 |
4:25PM |
GB 3, NO 38 |
| Regular Season: Week 2 |
Saints |
at |
 Panthers |
Sunday, September 19, 2021 |
1:00PM |
NO 7, CAR 26 |
| Regular Season: Week 3 |
Saints |
at |
 Patriots |
Sunday, September 26, 2021 |
1:00PM |
NO 28, NE 13 |
| Regular Season: Week 4 |
 Giants |
at |
Saints |
Sunday, October 3, 2021 |
1:00PM |
NYG 27, NO 21 |
| Regular Season: Week 5 |
Saints |
at |
 Washington |
Sunday, October 10, 2021 |
1:00PM |
NO 33, WSH 22 |
| Regular Season: Week 7 |
Saints |
at |
 Seahawks |
Monday, October 25, 2021 |
8:15PM |
NO 13, SEA 10 |
| Regular Season: Week 8 |
 Buccaneers |
at |
Saints |
Sunday, October 31, 2021 |
4:25PM |
TB 27, NO 36 |
| Regular Season: Week 9 |
 Falcons |
at |
Saints |
Sunday, November 7, 2021 |
1:00PM |
ATL 27, NO 25 |
| Regular Season: Week 10 |
Saints |
at |
 Titans |
Sunday, November 14, 2021 |
1:00PM |
NO 21, TEN 23 |
| Regular Season: Week 11 |
Saints |
at |
 Eagles |
Sunday, November 21, 2021 |
1:00PM |
NO 29, PHI 40 |
| Regular Season: Week 12 |
 Bills |
at |
Saints |
Thursday, November 25, 2021 |
8:20PM |
BUF 31, NO 6 |
| Regular Season: Week 13 |
 Cowboys |
at |
Saints |
Thursday, December 2, 2021 |
8:20PM |
DAL 27, NO 17 |
| Regular Season: Week 14 |
Saints |
at |
 Jets |
Sunday, December 12, 2021 |
1:00PM |
NO 30, NYJ 9 |
| Regular Season: Week 15 |
Saints |
at |
Buccaneers |
Sunday, December 19, 2021 |
8:20PM |
NO 9, TB 0 |
| Regular Season: Week 16 |
 Dolphins |
at |
Saints |
Monday, December 27, 2021 |
8:15PM |
MIA 20, NO 3 |
| Regular Season: Week 17 |
Panthers |
at |
Saints |
Sunday, January 2, 2022 |
1:00PM |
CAR 10, NO 18 |
| Regular Season: Week 18 |
Saints |
at |
Falcons |
Sunday, January 9, 2022 |
1:00PM |
NO 30, ATL 20 |