| Regular Season: Week 1 |
 Chargers |
at |
 Seahawks |
Sunday, September 7, 1980 |
3:00PM |
SD 34, SEA 13 |
| Regular Season: Week 2 |
Seahawks |
at |
 Chiefs |
Sunday, September 14, 1980 |
3:00PM |
SEA 17, KC 16 |
| Regular Season: Week 3 |
 Patriots |
at |
Seahawks |
Sunday, September 21, 1980 |
3:00PM |
NE 37, SEA 31 |
| Regular Season: Week 4 |
Seahawks |
at |
 Redskins |
Sunday, September 28, 1980 |
3:00PM |
SEA 14, WAS 0 |
| Regular Season: Week 5 |
Seahawks |
at |
 Oilers |
Sunday, October 5, 1980 |
3:00PM |
SEA 26, HOU 7 |
| Regular Season: Week 6 |
 Browns |
at |
Seahawks |
Sunday, October 12, 1980 |
3:00PM |
CLE 27, SEA 3 |
| Regular Season: Week 7 |
Seahawks |
at |
 Jets |
Sunday, October 19, 1980 |
3:00PM |
SEA 27, NYJ 17 |
| Regular Season: Week 8 |
Seahawks |
at |
 Raiders |
Sunday, October 26, 1980 |
2:00PM |
SEA 14, OAK 33 |
| Regular Season: Week 9 |
 Eagles |
at |
Seahawks |
Sunday, November 2, 1980 |
3:00PM |
PHI 27, SEA 20 |
| Regular Season: Week 10 |
Chiefs |
at |
Seahawks |
Sunday, November 9, 1980 |
3:00PM |
KC 31, SEA 30 |
| Regular Season: Week 11 |
Raiders |
at |
Seahawks |
Monday, November 17, 1980 |
3:00PM |
OAK 19, SEA 17 |
| Regular Season: Week 12 |
Seahawks |
at |
 Broncos |
Sunday, November 23, 1980 |
3:00PM |
SEA 20, DEN 36 |
| Regular Season: Week 13 |
Seahawks |
at |
 Cowboys |
Thursday, November 27, 1980 |
3:00PM |
SEA 7, DAL 51 |
| Regular Season: Week 14 |
 Giants |
at |
Seahawks |
Sunday, December 7, 1980 |
3:00PM |
NYG 27, SEA 21 |
| Regular Season: Week 15 |
Seahawks |
at |
Chargers |
Saturday, December 13, 1980 |
3:00PM |
SEA 14, SD 21 |
| Regular Season: Week 16 |
Broncos |
at |
Seahawks |
Sunday, December 21, 1980 |
3:00PM |
DEN 25, SEA 17 |