| Regular Season: Week 1 |
 Seahawks |
at |
 Bengals |
Sunday, September 6, 1981 |
3:00PM |
SEA 21, CIN 27 |
| Regular Season: Week 2 |
 Broncos |
at |
Seahawks |
Sunday, September 13, 1981 |
3:00PM |
DEN 10, SEA 13 |
| Regular Season: Week 3 |
Seahawks |
at |
 Raiders |
Sunday, September 20, 1981 |
3:00PM |
SEA 10, OAK 20 |
| Regular Season: Week 4 |
 Chiefs |
at |
Seahawks |
Sunday, September 27, 1981 |
3:00PM |
KC 20, SEA 14 |
| Regular Season: Week 5 |
Seahawks |
at |
 Chargers |
Sunday, October 4, 1981 |
3:00PM |
SEA 10, SD 24 |
| Regular Season: Week 6 |
Seahawks |
at |
 Oilers |
Sunday, October 11, 1981 |
3:00PM |
SEA 17, HOU 35 |
| Regular Season: Week 7 |
 Giants |
at |
Seahawks |
Sunday, October 18, 1981 |
3:00PM |
NYG 32, SEA 0 |
| Regular Season: Week 8 |
Seahawks |
at |
 Jets |
Sunday, October 25, 1981 |
2:00PM |
SEA 19, NYJ 3 |
| Regular Season: Week 9 |
Seahawks |
at |
 Packers |
Sunday, November 1, 1981 |
3:00PM |
SEA 24, GB 34 |
| Regular Season: Week 10 |
 Steelers |
at |
Seahawks |
Sunday, November 8, 1981 |
3:00PM |
PIT 21, SEA 24 |
| Regular Season: Week 11 |
Chargers |
at |
Seahawks |
Monday, November 16, 1981 |
3:00PM |
SD 23, SEA 44 |
| Regular Season: Week 12 |
Seahawks |
at |
Chiefs |
Sunday, November 22, 1981 |
3:00PM |
SEA 13, KC 40 |
| Regular Season: Week 13 |
Raiders |
at |
Seahawks |
Sunday, November 29, 1981 |
3:00PM |
OAK 32, SEA 31 |
| Regular Season: Week 14 |
Jets |
at |
Seahawks |
Sunday, December 6, 1981 |
3:00PM |
NYJ 23, SEA 27 |
| Regular Season: Week 15 |
Seahawks |
at |
Broncos |
Sunday, December 13, 1981 |
3:00PM |
SEA 13, DEN 23 |
| Regular Season: Week 16 |
 Browns |
at |
Seahawks |
Sunday, December 20, 1981 |
3:00PM |
CLE 21, SEA 42 |