| Regular Season: Week 1 |
 Seahawks |
at |
 Dolphins |
Sunday, September 3, 2000 |
4:15PM |
SEA 0, MIA 23 |
| Regular Season: Week 2 |
 Rams |
at |
Seahawks |
Sunday, September 10, 2000 |
4:15PM |
STL 37, SEA 34 |
| Regular Season: Week 3 |
 Saints |
at |
Seahawks |
Sunday, September 17, 2000 |
4:15PM |
NO 10, SEA 20 |
| Regular Season: Week 4 |
Seahawks |
at |
 Chargers |
Sunday, September 24, 2000 |
4:15PM |
SEA 20, SD 12 |
| Regular Season: Week 5 |
Seahawks |
at |
 Chiefs |
Monday, October 2, 2000 |
9:00PM |
SEA 17, KC 24 |
| Regular Season: Week 6 |
Seahawks |
at |
 Panthers |
Sunday, October 8, 2000 |
4:15PM |
SEA 3, CAR 26 |
| Regular Season: Week 7 |
 Colts |
at |
Seahawks |
Sunday, October 15, 2000 |
4:05PM |
IND 37, SEA 24 |
| Regular Season: Week 8 |
Seahawks |
at |
 Raiders |
Sunday, October 22, 2000 |
4:05PM |
SEA 3, OAK 31 |
| Regular Season: Week 9 |
Chiefs |
at |
Seahawks |
Sunday, October 29, 2000 |
4:15PM |
KC 24, SEA 19 |
| Regular Season: Week 10 |
Chargers |
at |
Seahawks |
Sunday, November 5, 2000 |
4:15PM |
SD 15, SEA 17 |
| Regular Season: Week 11 |
Seahawks |
at |
 Jaguars |
Sunday, November 12, 2000 |
1:00PM |
SEA 28, JAC 21 |
| Regular Season: Week 13 |
 Broncos |
at |
Seahawks |
Sunday, November 26, 2000 |
4:15PM |
DEN 38, SEA 31 |
| Regular Season: Week 14 |
Seahawks |
at |
 Falcons |
Sunday, December 3, 2000 |
1:00PM |
SEA 30, ATL 10 |
| Regular Season: Week 15 |
Seahawks |
at |
Broncos |
Sunday, December 10, 2000 |
4:05PM |
SEA 24, DEN 31 |
| Regular Season: Week 16 |
Raiders |
at |
Seahawks |
Saturday, December 16, 2000 |
4:05PM |
OAK 24, SEA 27 |
| Regular Season: Week 17 |
 Bills |
at |
Seahawks |
Saturday, December 23, 2000 |
8:20PM |
BUF 42, SEA 23 |