| Regular Season: Week 1 |
 Oilers |
at |
 Steelers |
Sunday, September 7, 1980 |
3:00PM |
HOU 17, PIT 31 |
| Regular Season: Week 2 |
Steelers |
at |
 Colts |
Sunday, September 14, 1980 |
3:00PM |
PIT 20, BAL 17 |
| Regular Season: Week 3 |
Steelers |
at |
 Bengals |
Sunday, September 21, 1980 |
3:00PM |
PIT 28, CIN 30 |
| Regular Season: Week 4 |
 Bears |
at |
Steelers |
Sunday, September 28, 1980 |
3:00PM |
CHI 3, PIT 38 |
| Regular Season: Week 5 |
Steelers |
at |
 Vikings |
Sunday, October 5, 1980 |
3:00PM |
PIT 23, MIN 17 |
| Regular Season: Week 6 |
Bengals |
at |
Steelers |
Sunday, October 12, 1980 |
3:00PM |
CIN 17, PIT 16 |
| Regular Season: Week 7 |
 Raiders |
at |
Steelers |
Monday, October 20, 1980 |
3:00PM |
OAK 45, PIT 34 |
| Regular Season: Week 8 |
Steelers |
at |
 Browns |
Sunday, October 26, 1980 |
2:00PM |
PIT 26, CLE 27 |
| Regular Season: Week 9 |
 Packers |
at |
Steelers |
Sunday, November 2, 1980 |
3:00PM |
GB 20, PIT 22 |
| Regular Season: Week 10 |
Steelers |
at |
 Buccaneers |
Sunday, November 9, 1980 |
3:00PM |
PIT 24, TB 21 |
| Regular Season: Week 11 |
Browns |
at |
Steelers |
Sunday, November 16, 1980 |
3:00PM |
CLE 13, PIT 16 |
| Regular Season: Week 12 |
Steelers |
at |
 Bills |
Sunday, November 23, 1980 |
3:00PM |
PIT 13, BUF 28 |
| Regular Season: Week 13 |
 Dolphins |
at |
Steelers |
Sunday, November 30, 1980 |
3:00PM |
MIA 10, PIT 23 |
| Regular Season: Week 14 |
Steelers |
at |
Oilers |
Thursday, December 4, 1980 |
3:00PM |
PIT 0, HOU 6 |
| Regular Season: Week 15 |
 Chiefs |
at |
Steelers |
Sunday, December 14, 1980 |
3:00PM |
KC 16, PIT 21 |
| Regular Season: Week 16 |
Steelers |
at |
 Chargers |
Monday, December 22, 1980 |
3:00PM |
PIT 17, SD 26 |