| Regular Season: Week 1 |
 Chiefs |
at |
 Steelers |
Sunday, September 6, 1981 |
3:00PM |
KC 37, PIT 33 |
| Regular Season: Week 2 |
Steelers |
at |
 Dolphins |
Thursday, September 10, 1981 |
3:00PM |
PIT 10, MIA 30 |
| Regular Season: Week 3 |
 Jets |
at |
Steelers |
Sunday, September 20, 1981 |
3:00PM |
NYJ 10, PIT 38 |
| Regular Season: Week 4 |
 Patriots |
at |
Steelers |
Sunday, September 27, 1981 |
3:00PM |
NE 21, PIT 27 |
| Regular Season: Week 5 |
Steelers |
at |
 Saints |
Sunday, October 4, 1981 |
3:00PM |
PIT 20, NO 6 |
| Regular Season: Week 6 |
 Browns |
at |
Steelers |
Sunday, October 11, 1981 |
3:00PM |
CLE 7, PIT 13 |
| Regular Season: Week 7 |
Steelers |
at |
 Bengals |
Sunday, October 18, 1981 |
3:00PM |
PIT 7, CIN 34 |
| Regular Season: Week 8 |
 Oilers |
at |
Steelers |
Monday, October 26, 1981 |
3:00PM |
HOU 13, PIT 26 |
| Regular Season: Week 9 |
 49ers |
at |
Steelers |
Sunday, November 1, 1981 |
3:00PM |
SF 17, PIT 14 |
| Regular Season: Week 10 |
Steelers |
at |
 Seahawks |
Sunday, November 8, 1981 |
3:00PM |
PIT 21, SEA 24 |
| Regular Season: Week 11 |
Steelers |
at |
 Falcons |
Sunday, November 15, 1981 |
3:00PM |
PIT 34, ATL 20 |
| Regular Season: Week 12 |
Steelers |
at |
Browns |
Sunday, November 22, 1981 |
3:00PM |
PIT 32, CLE 10 |
| Regular Season: Week 13 |
 Rams |
at |
Steelers |
Sunday, November 29, 1981 |
3:00PM |
LA 0, PIT 24 |
| Regular Season: Week 14 |
Steelers |
at |
 Raiders |
Monday, December 7, 1981 |
3:00PM |
PIT 27, OAK 30 |
| Regular Season: Week 15 |
Bengals |
at |
Steelers |
Sunday, December 13, 1981 |
3:00PM |
CIN 17, PIT 10 |
| Regular Season: Week 16 |
Steelers |
at |
Oilers |
Sunday, December 20, 1981 |
3:00PM |
PIT 20, HOU 21 |