| Regular Season: Week 1 |
 Cowboys |
at |
 Steelers |
Sunday, September 4, 1988 |
3:00PM |
DAL 21, PIT 24 |
| Regular Season: Week 2 |
Steelers |
at |
 Redskins |
Sunday, September 11, 1988 |
3:00PM |
PIT 29, WAS 30 |
| Regular Season: Week 3 |
 Bengals |
at |
Steelers |
Sunday, September 18, 1988 |
3:00PM |
CIN 17, PIT 12 |
| Regular Season: Week 4 |
Steelers |
at |
 Bills |
Sunday, September 25, 1988 |
3:00PM |
PIT 28, BUF 36 |
| Regular Season: Week 5 |
 Browns |
at |
Steelers |
Sunday, October 2, 1988 |
3:00PM |
CLE 23, PIT 9 |
| Regular Season: Week 6 |
Steelers |
at |
 Cardinals |
Sunday, October 9, 1988 |
3:00PM |
PIT 14, PHO 31 |
| Regular Season: Week 7 |
 Oilers |
at |
Steelers |
Sunday, October 16, 1988 |
3:00PM |
HOU 34, PIT 14 |
| Regular Season: Week 8 |
 Broncos |
at |
Steelers |
Sunday, October 23, 1988 |
3:00PM |
DEN 21, PIT 39 |
| Regular Season: Week 9 |
Steelers |
at |
 Jets |
Sunday, October 30, 1988 |
2:00PM |
PIT 20, NYJ 24 |
| Regular Season: Week 10 |
Steelers |
at |
Bengals |
Sunday, November 6, 1988 |
3:00PM |
PIT 7, CIN 42 |
| Regular Season: Week 11 |
 Eagles |
at |
Steelers |
Sunday, November 13, 1988 |
3:00PM |
PHI 27, PIT 26 |
| Regular Season: Week 12 |
Steelers |
at |
Browns |
Sunday, November 20, 1988 |
3:00PM |
PIT 7, CLE 27 |
| Regular Season: Week 13 |
 Chiefs |
at |
Steelers |
Sunday, November 27, 1988 |
3:00PM |
KC 10, PIT 16 |
| Regular Season: Week 14 |
Steelers |
at |
Oilers |
Sunday, December 4, 1988 |
3:00PM |
PIT 37, HOU 34 |
| Regular Season: Week 15 |
Steelers |
at |
 Chargers |
Sunday, December 11, 1988 |
3:00PM |
PIT 14, SD 20 |
| Regular Season: Week 16 |
 Dolphins |
at |
Steelers |
Sunday, December 18, 1988 |
3:00PM |
MIA 24, PIT 40 |