| Regular Season: Week 1 |
 Steelers |
at |
 Bills |
Sunday, September 12, 2021 |
1:00PM |
PIT 23, BUF 16 |
| Regular Season: Week 2 |
 Raiders |
at |
Steelers |
Sunday, September 19, 2021 |
1:00PM |
LV 26, PIT 17 |
| Regular Season: Week 3 |
 Bengals |
at |
Steelers |
Sunday, September 26, 2021 |
1:00PM |
CIN 24, PIT 10 |
| Regular Season: Week 4 |
Steelers |
at |
 Packers |
Sunday, October 3, 2021 |
4:25PM |
PIT 17, GB 27 |
| Regular Season: Week 5 |
 Broncos |
at |
Steelers |
Sunday, October 10, 2021 |
1:00PM |
DEN 19, PIT 27 |
| Regular Season: Week 6 |
 Seahawks |
at |
Steelers |
Sunday, October 17, 2021 |
8:20PM |
SEA 20, PIT 23 |
| Regular Season: Week 8 |
Steelers |
at |
 Browns |
Sunday, October 31, 2021 |
1:00PM |
PIT 15, CLE 10 |
| Regular Season: Week 9 |
 Bears |
at |
Steelers |
Monday, November 8, 2021 |
8:15PM |
CHI 27, PIT 29 |
| Regular Season: Week 10 |
 Lions |
at |
Steelers |
Sunday, November 14, 2021 |
1:00PM |
DET 16, PIT 16 |
| Regular Season: Week 11 |
Steelers |
at |
 Chargers |
Sunday, November 21, 2021 |
8:20PM |
PIT 37, LAC 41 |
| Regular Season: Week 12 |
Steelers |
at |
Bengals |
Sunday, November 28, 2021 |
1:00PM |
PIT 10, CIN 41 |
| Regular Season: Week 13 |
 Ravens |
at |
Steelers |
Sunday, December 5, 2021 |
4:25PM |
BAL 19, PIT 20 |
| Regular Season: Week 14 |
Steelers |
at |
 Vikings |
Thursday, December 9, 2021 |
8:20PM |
PIT 28, MIN 36 |
| Regular Season: Week 15 |
 Titans |
at |
Steelers |
Sunday, December 19, 2021 |
1:00PM |
TEN 13, PIT 19 |
| Regular Season: Week 16 |
Steelers |
at |
 Chiefs |
Sunday, December 26, 2021 |
4:25PM |
PIT 10, KC 36 |
| Regular Season: Week 17 |
Browns |
at |
Steelers |
Monday, January 3, 2022 |
8:15PM |
CLE 14, PIT 26 |
| Regular Season: Week 18 |
Steelers |
at |
Ravens |
Sunday, January 9, 2022 |
1:00PM |
PIT 16, BAL 13 |