| Regular Season: Week 1 |
 Colts |
at |
 Texans |
Sunday, September 12, 2010 |
1:00PM |
IND 24, HOU 34 |
| Regular Season: Week 2 |
Texans |
at |
 Redskins |
Sunday, September 19, 2010 |
4:15PM |
HOU 30, WAS 27 |
| Regular Season: Week 3 |
 Cowboys |
at |
Texans |
Sunday, September 26, 2010 |
1:00PM |
DAL 27, HOU 13 |
| Regular Season: Week 4 |
Texans |
at |
 Raiders |
Sunday, October 3, 2010 |
4:05PM |
HOU 31, OAK 24 |
| Regular Season: Week 5 |
 Giants |
at |
Texans |
Sunday, October 10, 2010 |
1:00PM |
NYG 34, HOU 10 |
| Regular Season: Week 6 |
 Chiefs |
at |
Texans |
Sunday, October 17, 2010 |
1:00PM |
KC 31, HOU 35 |
| Regular Season: Week 8 |
Texans |
at |
Colts |
Monday, November 1, 2010 |
8:30PM |
HOU 17, IND 30 |
| Regular Season: Week 9 |
 Chargers |
at |
Texans |
Sunday, November 7, 2010 |
1:00PM |
SD 29, HOU 23 |
| Regular Season: Week 10 |
Texans |
at |
 Jaguars |
Sunday, November 14, 2010 |
1:00PM |
HOU 24, JAC 31 |
| Regular Season: Week 11 |
Texans |
at |
 Jets |
Sunday, November 21, 2010 |
1:00PM |
HOU 27, NYJ 30 |
| Regular Season: Week 12 |
 Titans |
at |
Texans |
Sunday, November 28, 2010 |
1:00PM |
TEN 0, HOU 20 |
| Regular Season: Week 13 |
Texans |
at |
 Eagles |
Thursday, December 2, 2010 |
8:20PM |
HOU 24, PHI 34 |
| Regular Season: Week 14 |
 Ravens |
at |
Texans |
Monday, December 13, 2010 |
8:30PM |
BAL 34, HOU 28 |
| Regular Season: Week 15 |
Texans |
at |
Titans |
Sunday, December 19, 2010 |
1:00PM |
HOU 17, TEN 31 |
| Regular Season: Week 16 |
Texans |
at |
 Broncos |
Sunday, December 26, 2010 |
4:05PM |
HOU 23, DEN 24 |
| Regular Season: Week 17 |
Jaguars |
at |
Texans |
Sunday, January 2, 2011 |
4:15PM |
JAC 17, HOU 34 |