| Regular Season: Week 1 |
 Cardinals |
at |
 Titans |
Sunday, September 12, 2021 |
1:00PM |
ARI 38, TEN 13 |
| Regular Season: Week 2 |
Titans |
at |
 Seahawks |
Sunday, September 19, 2021 |
4:25PM |
TEN 33, SEA 30 |
| Regular Season: Week 3 |
 Colts |
at |
Titans |
Sunday, September 26, 2021 |
1:00PM |
IND 16, TEN 25 |
| Regular Season: Week 4 |
Titans |
at |
 Jets |
Sunday, October 3, 2021 |
1:00PM |
TEN 24, NYJ 27 |
| Regular Season: Week 5 |
Titans |
at |
 Jaguars |
Sunday, October 10, 2021 |
1:00PM |
TEN 37, JAX 19 |
| Regular Season: Week 6 |
 Bills |
at |
Titans |
Monday, October 18, 2021 |
8:15PM |
BUF 31, TEN 34 |
| Regular Season: Week 7 |
 Chiefs |
at |
Titans |
Sunday, October 24, 2021 |
1:00PM |
KC 3, TEN 27 |
| Regular Season: Week 8 |
Titans |
at |
Colts |
Sunday, October 31, 2021 |
1:00PM |
TEN 34, IND 31 |
| Regular Season: Week 9 |
Titans |
at |
 Rams |
Sunday, November 7, 2021 |
8:20PM |
TEN 28, LAR 16 |
| Regular Season: Week 10 |
 Saints |
at |
Titans |
Sunday, November 14, 2021 |
1:00PM |
NO 21, TEN 23 |
| Regular Season: Week 11 |
 Texans |
at |
Titans |
Sunday, November 21, 2021 |
1:00PM |
HOU 22, TEN 13 |
| Regular Season: Week 12 |
Titans |
at |
 Patriots |
Sunday, November 28, 2021 |
1:00PM |
TEN 13, NE 36 |
| Regular Season: Week 14 |
Jaguars |
at |
Titans |
Sunday, December 12, 2021 |
1:00PM |
JAX 0, TEN 20 |
| Regular Season: Week 15 |
Titans |
at |
 Steelers |
Sunday, December 19, 2021 |
1:00PM |
TEN 13, PIT 19 |
| Regular Season: Week 16 |
 49ers |
at |
Titans |
Thursday, December 23, 2021 |
8:20PM |
SF 17, TEN 20 |
| Regular Season: Week 17 |
 Dolphins |
at |
Titans |
Sunday, January 2, 2022 |
1:00PM |
MIA 3, TEN 34 |
| Regular Season: Week 18 |
Titans |
at |
Texans |
Sunday, January 9, 2022 |
1:00PM |
TEN 28, HOU 25 |