| Regular Season: Week 1 |
 Falcons |
at |
 Vikings |
Sunday, September 7, 1980 |
3:00PM |
ATL 23, MIN 24 |
| Regular Season: Week 2 |
 Eagles |
at |
Vikings |
Sunday, September 14, 1980 |
3:00PM |
PHI 42, MIN 7 |
| Regular Season: Week 3 |
Vikings |
at |
 Bears |
Sunday, September 21, 1980 |
3:00PM |
MIN 34, CHI 14 |
| Regular Season: Week 4 |
Vikings |
at |
 Lions |
Sunday, September 28, 1980 |
3:00PM |
MIN 7, DET 27 |
| Regular Season: Week 5 |
 Steelers |
at |
Vikings |
Sunday, October 5, 1980 |
3:00PM |
PIT 23, MIN 17 |
| Regular Season: Week 6 |
Bears |
at |
Vikings |
Sunday, October 12, 1980 |
3:00PM |
CHI 7, MIN 13 |
| Regular Season: Week 7 |
Vikings |
at |
 Bengals |
Sunday, October 19, 1980 |
3:00PM |
MIN 0, CIN 14 |
| Regular Season: Week 8 |
Vikings |
at |
 Packers |
Sunday, October 26, 1980 |
2:00PM |
MIN 3, GB 16 |
| Regular Season: Week 9 |
Vikings |
at |
 Redskins |
Sunday, November 2, 1980 |
3:00PM |
MIN 39, WAS 14 |
| Regular Season: Week 10 |
Lions |
at |
Vikings |
Sunday, November 9, 1980 |
3:00PM |
DET 0, MIN 34 |
| Regular Season: Week 11 |
 Buccaneers |
at |
Vikings |
Sunday, November 16, 1980 |
3:00PM |
TB 30, MIN 38 |
| Regular Season: Week 12 |
Packers |
at |
Vikings |
Sunday, November 23, 1980 |
3:00PM |
GB 25, MIN 13 |
| Regular Season: Week 13 |
Vikings |
at |
 Saints |
Sunday, November 30, 1980 |
3:00PM |
MIN 23, NO 20 |
| Regular Season: Week 14 |
Vikings |
at |
Buccaneers |
Sunday, December 7, 1980 |
3:00PM |
MIN 21, TB 10 |
| Regular Season: Week 15 |
 Browns |
at |
Vikings |
Sunday, December 14, 1980 |
3:00PM |
CLE 23, MIN 28 |
| Regular Season: Week 16 |
Vikings |
at |
 Oilers |
Sunday, December 21, 1980 |
3:00PM |
MIN 16, HOU 20 |
| Divisional Playoffs: Week 18 |
Vikings |
at |
Eagles |
Saturday, January 3, 1981 |
3:00PM |
MIN 16, PHI 31 |