Buffalo Bills 2006 Season Schedule & Scores
| Overall record: | 7-9 |
| Home record: | 4-4 |
| Away record: | 3-5 |
Despite a rough beginning to the 2006 season with four straight losses, the Buffalo Bills showed resilience by winning seven of their last 12 games. Nonetheless, their efforts weren't enough to secure a playoff spot, as they ended the season with a 7-9 record.
| Away | Home | Date | Result | ||
|---|---|---|---|---|---|
 BUF | @ |  NE | Sun, Sep 10th, 2006 | L17-19 | |
| BUF | @ |  MIA | Sun, Sep 17th, 2006 | W16-6 | |
 NYJ | @ | BUF | Sun, Sep 24th, 2006 | W28-20 | |
 MIN | @ | BUF | Sun, Oct 1st, 2006 | L12-17 | |
| BUF | @ |  CHI | Sun, Oct 8th, 2006 | L7-40 | |
| BUF | @ |  DET | Sun, Oct 15th, 2006 | L17-20 | |
| NE | @ | BUF | Sun, Oct 22nd, 2006 | W28-6 | |
 GB | @ | BUF | Sun, Nov 5th, 2006 | L10-24 | |
| BUF | @ |  IND | Sun, Nov 12th, 2006 | L16-17 | |
| BUF | @ |  HOU | Sun, Nov 19th, 2006 | W24-21 | |
 JAX | @ | BUF | Sun, Nov 26th, 2006 | L24-27 | |
 SD | @ | BUF | Sun, Dec 3rd, 2006 | W24-21 | |
| BUF | @ | NYJ | Sun, Dec 10th, 2006 | W31-13 | |
| MIA | @ | BUF | Sun, Dec 17th, 2006 | L0-21 | |
 TEN | @ | BUF | Sun, Dec 24th, 2006 | W30-29 | |
| BUF | @ |  BAL | Sun, Dec 31st, 2006 | L7-19 |
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