| Regular Season: Week 1 |
 Seahawks |
at |
 Colts |
Sunday, September 12, 2021 |
1:00PM |
SEA 28, IND 16 |
| Regular Season: Week 2 |
 Rams |
at |
Colts |
Sunday, September 19, 2021 |
1:00PM |
LAR 27, IND 24 |
| Regular Season: Week 3 |
Colts |
at |
 Titans |
Sunday, September 26, 2021 |
1:00PM |
IND 16, TEN 25 |
| Regular Season: Week 4 |
Colts |
at |
 Dolphins |
Sunday, October 3, 2021 |
1:00PM |
IND 27, MIA 17 |
| Regular Season: Week 5 |
Colts |
at |
 Ravens |
Monday, October 11, 2021 |
8:15PM |
IND 25, BAL 31 |
| Regular Season: Week 6 |
 Texans |
at |
Colts |
Sunday, October 17, 2021 |
1:00PM |
HOU 3, IND 31 |
| Regular Season: Week 7 |
Colts |
at |
 49ers |
Sunday, October 24, 2021 |
8:20PM |
IND 30, SF 18 |
| Regular Season: Week 8 |
Titans |
at |
Colts |
Sunday, October 31, 2021 |
1:00PM |
TEN 34, IND 31 |
| Regular Season: Week 9 |
 Jets |
at |
Colts |
Thursday, November 4, 2021 |
8:20PM |
NYJ 30, IND 45 |
| Regular Season: Week 10 |
 Jaguars |
at |
Colts |
Sunday, November 14, 2021 |
1:00PM |
JAX 17, IND 23 |
| Regular Season: Week 11 |
Colts |
at |
 Bills |
Sunday, November 21, 2021 |
1:00PM |
IND 41, BUF 15 |
| Regular Season: Week 12 |
 Buccaneers |
at |
Colts |
Sunday, November 28, 2021 |
1:00PM |
TB 38, IND 31 |
| Regular Season: Week 13 |
Colts |
at |
Texans |
Sunday, December 5, 2021 |
1:00PM |
IND 31, HOU 0 |
| Regular Season: Week 15 |
 Patriots |
at |
Colts |
Sunday, December 19, 2021 |
TBD |
NE 17, IND 27 |
| Regular Season: Week 16 |
Colts |
at |
 Cardinals |
Saturday, December 25, 2021 |
8:15PM |
IND 22, ARI 16 |
| Regular Season: Week 17 |
 Raiders |
at |
Colts |
Sunday, January 2, 2022 |
1:00PM |
LV 23, IND 20 |
| Regular Season: Week 18 |
Colts |
at |
Jaguars |
Sunday, January 9, 2022 |
1:00PM |
IND 11, JAX 26 |