| Regular Season: Week 1 |
 Chargers |
at |
 Seahawks |
Sunday, September 3, 1978 |
3:00PM |
SD 24, SEA 20 |
| Regular Season: Week 2 |
Seahawks |
at |
 Steelers |
Sunday, September 10, 1978 |
3:00PM |
SEA 10, PIT 21 |
| Regular Season: Week 3 |
Seahawks |
at |
 Jets |
Sunday, September 17, 1978 |
3:00PM |
SEA 24, NYJ 17 |
| Regular Season: Week 4 |
 Lions |
at |
Seahawks |
Sunday, September 24, 1978 |
3:00PM |
DET 16, SEA 28 |
| Regular Season: Week 5 |
Seahawks |
at |
 Broncos |
Sunday, October 1, 1978 |
3:00PM |
SEA 7, DEN 28 |
| Regular Season: Week 6 |
 Vikings |
at |
Seahawks |
Sunday, October 8, 1978 |
3:00PM |
MIN 28, SEA 29 |
| Regular Season: Week 7 |
Seahawks |
at |
 Packers |
Sunday, October 15, 1978 |
3:00PM |
SEA 28, GB 45 |
| Regular Season: Week 8 |
 Raiders |
at |
Seahawks |
Sunday, October 22, 1978 |
3:00PM |
OAK 7, SEA 27 |
| Regular Season: Week 9 |
Broncos |
at |
Seahawks |
Sunday, October 29, 1978 |
2:00PM |
DEN 20, SEA 17 |
| Regular Season: Week 10 |
Seahawks |
at |
 Bears |
Sunday, November 5, 1978 |
3:00PM |
SEA 31, CHI 29 |
| Regular Season: Week 11 |
 Colts |
at |
Seahawks |
Sunday, November 12, 1978 |
3:00PM |
BAL 17, SEA 14 |
| Regular Season: Week 12 |
Seahawks |
at |
 Chiefs |
Sunday, November 19, 1978 |
3:00PM |
SEA 13, KC 10 |
| Regular Season: Week 13 |
Seahawks |
at |
Raiders |
Sunday, November 26, 1978 |
3:00PM |
SEA 17, OAK 16 |
| Regular Season: Week 14 |
 Browns |
at |
Seahawks |
Sunday, December 3, 1978 |
3:00PM |
CLE 24, SEA 47 |
| Regular Season: Week 15 |
Seahawks |
at |
Chargers |
Sunday, December 10, 1978 |
3:00PM |
SEA 10, SD 37 |
| Regular Season: Week 16 |
Chiefs |
at |
Seahawks |
Sunday, December 17, 1978 |
3:00PM |
KC 19, SEA 23 |