| Regular Season: Week 1 |
 Bills |
at |
 Chiefs |
Sunday, September 11, 2011 |
1:00PM |
BUF 41, KC 7 |
| Regular Season: Week 2 |
 Raiders |
at |
Bills |
Sunday, September 18, 2011 |
1:00PM |
OAK 35, BUF 38 |
| Regular Season: Week 3 |
 Patriots |
at |
Bills |
Sunday, September 25, 2011 |
1:00PM |
NE 31, BUF 34 |
| Regular Season: Week 4 |
Bills |
at |
 Bengals |
Sunday, October 2, 2011 |
1:00PM |
BUF 20, CIN 23 |
| Regular Season: Week 5 |
 Eagles |
at |
Bills |
Sunday, October 9, 2011 |
1:00PM |
PHI 24, BUF 31 |
| Regular Season: Week 6 |
Bills |
at |
 Giants |
Sunday, October 16, 2011 |
1:00PM |
BUF 24, NYG 27 |
| Regular Season: Week 8 |
 Redskins |
at |
Bills |
Sunday, October 30, 2011 |
4:05PM |
WAS 0, BUF 23 |
| Regular Season: Week 9 |
 Jets |
at |
Bills |
Sunday, November 6, 2011 |
1:00PM |
NYJ 27, BUF 11 |
| Regular Season: Week 10 |
Bills |
at |
 Cowboys |
Sunday, November 13, 2011 |
1:00PM |
BUF 7, DAL 44 |
| Regular Season: Week 11 |
Bills |
at |
 Dolphins |
Sunday, November 20, 2011 |
1:00PM |
BUF 8, MIA 35 |
| Regular Season: Week 12 |
Bills |
at |
Jets |
Sunday, November 27, 2011 |
1:00PM |
BUF 24, NYJ 28 |
| Regular Season: Week 13 |
 Titans |
at |
Bills |
Sunday, December 4, 2011 |
1:00PM |
TEN 23, BUF 17 |
| Regular Season: Week 14 |
Bills |
at |
 Chargers |
Sunday, December 11, 2011 |
4:15PM |
BUF 10, SD 37 |
| Regular Season: Week 15 |
Dolphins |
at |
Bills |
Sunday, December 18, 2011 |
1:00PM |
MIA 30, BUF 23 |
| Regular Season: Week 16 |
 Broncos |
at |
Bills |
Saturday, December 24, 2011 |
1:00PM |
DEN 14, BUF 40 |
| Regular Season: Week 17 |
Bills |
at |
Patriots |
Sunday, January 1, 2012 |
1:00PM |
BUF 21, NE 49 |